Lipogenesis and lipolysis: the pathways exploited by the cancer cells to acquire fatty acids
N Zaidi, L Lupien, NB Kuemmerle, WB Kinlaw… - Progress in lipid …, 2013 - Elsevier
One of the most important metabolic hallmarks of cancer cells is enhanced lipogenesis.
Depending on the tumor type, tumor cells synthesize up to 95% of saturated and mono-
unsaturated fatty acids (FA) de novo in spite of sufficient dietary lipid supply. This lipogenic
conversion starts early when cells become cancerous and further expands as the tumor cells
become more malignant. It is suggested that activation of FA synthesis is required for
carcinogenesis and for tumor cell survival. These observations suggest that the enzymes …
Depending on the tumor type, tumor cells synthesize up to 95% of saturated and mono-
unsaturated fatty acids (FA) de novo in spite of sufficient dietary lipid supply. This lipogenic
conversion starts early when cells become cancerous and further expands as the tumor cells
become more malignant. It is suggested that activation of FA synthesis is required for
carcinogenesis and for tumor cell survival. These observations suggest that the enzymes …