[HTML][HTML] Molecular analysis of laminin N-terminal domains mediating self-interactions
U Odenthal, S Haehn, P Tunggal, B Merkl… - Journal of Biological …, 2004 - ASBMB
The ability of laminins to self-polymerize is crucial for the formation of basement membranes.
Development of this polymerized network has profound effects upon tissue architecture as
well as on the intracellular organization and differentiation of neighboring cells. The laminin
N-terminal (LN) domains have been shown to mediate this interaction and studies using
proteolytic fragments derived from laminin-1 led to the theory that network assembly
depends on the formation of a heterotrimeric complex between LN domains derived from α …
Development of this polymerized network has profound effects upon tissue architecture as
well as on the intracellular organization and differentiation of neighboring cells. The laminin
N-terminal (LN) domains have been shown to mediate this interaction and studies using
proteolytic fragments derived from laminin-1 led to the theory that network assembly
depends on the formation of a heterotrimeric complex between LN domains derived from α …