[HTML][HTML] Genetic disorders of the glomerular filtration barrier
AS Li, JF Ingham, R Lennon - … Journal of the American Society of …, 2020 - journals.lww.com
The glomerular filtration barrier is a highly specialized capillary wall comprising fenestrated
endothelial cells, podocytes, and an intervening basement membrane. In glomerular
disease, this barrier loses functional integrity, allowing the passage of macromolecules and
cells, and there are associated changes in both cell morphology and the extracellular matrix.
Over the past 3 decades, there has been a transformation in our understanding about
glomerular disease, fueled by genetic discovery, and this is leading to exciting advances in …
endothelial cells, podocytes, and an intervening basement membrane. In glomerular
disease, this barrier loses functional integrity, allowing the passage of macromolecules and
cells, and there are associated changes in both cell morphology and the extracellular matrix.
Over the past 3 decades, there has been a transformation in our understanding about
glomerular disease, fueled by genetic discovery, and this is leading to exciting advances in …