IL-33 promotes food anaphylaxis in epicutaneously sensitized mice by targeting mast cells
Background Cutaneous exposure to food allergens predisposes to food allergy, which is
commonly associated with atopic dermatitis (AD). Levels of the epithelial cytokine IL-33 are
increased in skin lesions and serum of patients with AD. Mast cells (MCs) play a critical role
in food-induced anaphylaxis and express the IL-33 receptor ST2. The role of IL-33 in
patients with MC-dependent food anaphylaxis is unknown. Objective We sought to
determine the role and mechanism of action of IL-33 in patients with food-induced …
commonly associated with atopic dermatitis (AD). Levels of the epithelial cytokine IL-33 are
increased in skin lesions and serum of patients with AD. Mast cells (MCs) play a critical role
in food-induced anaphylaxis and express the IL-33 receptor ST2. The role of IL-33 in
patients with MC-dependent food anaphylaxis is unknown. Objective We sought to
determine the role and mechanism of action of IL-33 in patients with food-induced …