The role of filaggrin loss-of-function mutations in atopic dermatitis
GM O'Regan, AD Irvine - Current opinion in allergy and clinical …, 2008 - journals.lww.com
GM O'Regan, AD Irvine
Current opinion in allergy and clinical immunology, 2008•journals.lww.comIn this review we highlight recent advances in our understanding of how filaggrin might
influence the environmental-immune interface, impacting disease penetrance, severity and
trajectory, and the implications for both research and therapeutics in this field. Focusing on
the downstream biological consequences of altered filaggrin expression and the sequence
of immunological and environmental triggers that ensue will provide the rationale for
targeted therapeutics capable of restoring or preventing disruption of barrier function.
influence the environmental-immune interface, impacting disease penetrance, severity and
trajectory, and the implications for both research and therapeutics in this field. Focusing on
the downstream biological consequences of altered filaggrin expression and the sequence
of immunological and environmental triggers that ensue will provide the rationale for
targeted therapeutics capable of restoring or preventing disruption of barrier function.
Summary
In this review we highlight recent advances in our understanding of how filaggrin might influence the environmental-immune interface, impacting disease penetrance, severity and trajectory, and the implications for both research and therapeutics in this field. Focusing on the downstream biological consequences of altered filaggrin expression and the sequence of immunological and environmental triggers that ensue will provide the rationale for targeted therapeutics capable of restoring or preventing disruption of barrier function.
Lippincott Williams & Wilkins