RNA sequencing atopic dermatitis transcriptome profiling provides insights into novel disease mechanisms with potential therapeutic implications
Background Genomic profiling of lesional and nonlesional skin of patients with atopic
dermatitis (AD) using microarrays has led to increased understanding of AD and
identification of novel therapeutic targets. However, the limitations of microarrays might
decrease detection of AD genes. These limitations might be lessened with next-generation
RNA sequencing (RNA-seq). Objective We sought to define the lesional AD transcriptome
using RNA-seq and compare it using microarrays performed on the same cohort. Methods …
dermatitis (AD) using microarrays has led to increased understanding of AD and
identification of novel therapeutic targets. However, the limitations of microarrays might
decrease detection of AD genes. These limitations might be lessened with next-generation
RNA sequencing (RNA-seq). Objective We sought to define the lesional AD transcriptome
using RNA-seq and compare it using microarrays performed on the same cohort. Methods …