Up-regulated expression of CXCL12 in human spleens with extramedullary haematopoiesis
Y Miwa, T Hayashi, S Suzuki, S Abe… - Pathology-Journal of …, 2013 - journals.lww.com
Aims: To determine the expression of CXCL12 in human spleens with extramedullary
haematopoiesis (EMH) for clarifying the association of splenic haematopoietic stem cells
(HSCs) with CXCL12, which has been demonstrated to be a marker of bone marrow niches.
Methods: We examined the expression of mRNA for CXCL12 by quantitative reverse
transcription polymerase chain reaction (RT-PCR) and localised the CXCL12 protein by
immunohistochemical staining in EMH negative and positive spleen samples from autopsy …
haematopoiesis (EMH) for clarifying the association of splenic haematopoietic stem cells
(HSCs) with CXCL12, which has been demonstrated to be a marker of bone marrow niches.
Methods: We examined the expression of mRNA for CXCL12 by quantitative reverse
transcription polymerase chain reaction (RT-PCR) and localised the CXCL12 protein by
immunohistochemical staining in EMH negative and positive spleen samples from autopsy …