PGE2 deficiency predisposes to anaphylaxis by causing mast cell hyperresponsiveness
S Rastogi, DM Willmes, M Nassiri, M Babina… - Journal of Allergy and …, 2020 - Elsevier
Background Reduced levels of prostaglandin E 2 (PGE 2) contribute to aspirin-induced
hypersensitivity. COX inhibitors are also frequent cofactors in anaphylaxis. Whether
alterations in the PGE 2 system contribute to anaphylaxis independently of COX inhibitor
intake is unclear. Objective Our aim was to test the hypothesis that relative PGE 2 deficiency
predisposes to anaphylaxis. Methods Sera from 48 patients with anaphylaxis and 27 healthy
subjects were analyzed for PGE 2 levels and correlated against severity; 9α, 11β-PGF 2 and …
hypersensitivity. COX inhibitors are also frequent cofactors in anaphylaxis. Whether
alterations in the PGE 2 system contribute to anaphylaxis independently of COX inhibitor
intake is unclear. Objective Our aim was to test the hypothesis that relative PGE 2 deficiency
predisposes to anaphylaxis. Methods Sera from 48 patients with anaphylaxis and 27 healthy
subjects were analyzed for PGE 2 levels and correlated against severity; 9α, 11β-PGF 2 and …