Ciglitazone is not itself thermogenic but increases the potential for thermogenesis in lean mice
PL Thurlby, S Wilson, JRS Arch - Bioscience Reports, 1987 - Springer
PL Thurlby, S Wilson, JRS Arch
Bioscience Reports, 1987•SpringerChronic dietary administration of the oral hypoglycaemic ciglitazone (3 g/day for 14–28
days) to lean, non-diabetic CD1 mice resulted in increased brown adipose tissue
mitochondrial GDP binding and a marked increase in the thermic effect of the beta-
adrenoceptor agonist BRL 26830A. However, ciglitazone was not itself thermogenic after an
acute dose, nor did it raise resting metabolic rate during chronic dietary dosing.
days) to lean, non-diabetic CD1 mice resulted in increased brown adipose tissue
mitochondrial GDP binding and a marked increase in the thermic effect of the beta-
adrenoceptor agonist BRL 26830A. However, ciglitazone was not itself thermogenic after an
acute dose, nor did it raise resting metabolic rate during chronic dietary dosing.
Abstract
Chronic dietary administration of the oral hypoglycaemic ciglitazone (3 g/day for 14–28 days) to lean, non-diabetic CD1 mice resulted in increased brown adipose tissue mitochondrial GDP binding and a marked increase in the thermic effect of the beta-adrenoceptor agonist BRL 26830A. However, ciglitazone was not itself thermogenic after an acute dose, nor did it raise resting metabolic rate during chronic dietary dosing.
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