Wiskott-Aldrich syndrome protein senses irradiation-induced DNA damage to coordinate the cell-protective Golgi dispersal response in human T and B lymphocytes
KK Wen, SS Han, YM Vyas - Journal of Allergy and Clinical Immunology, 2020 - Elsevier
Background Wiskott-Aldrich syndrome (WAS) is an X-linked primary immune deficiency
disorder resulting from Wiskott-Aldrich syndrome protein (WASp) deficiency. Lymphocytes
from patients with WAS manifest increased DNA damage and lymphopenia from cell death,
yet how WASp influences DNA damage–linked cell survival is unknown. A recently
described mechanism promoting cell survival after ionizing radiation (IR)–induced DNA
damage involves fragmentation and dispersal of the Golgi apparatus, known as the Golgi …
disorder resulting from Wiskott-Aldrich syndrome protein (WASp) deficiency. Lymphocytes
from patients with WAS manifest increased DNA damage and lymphopenia from cell death,
yet how WASp influences DNA damage–linked cell survival is unknown. A recently
described mechanism promoting cell survival after ionizing radiation (IR)–induced DNA
damage involves fragmentation and dispersal of the Golgi apparatus, known as the Golgi …