[HTML][HTML] Reduced type I interferon production by dendritic cells and weakened antiviral immunity in patients with Wiskott-Aldrich syndrome protein deficiency
PA Lang, N Shaabani, S Borkens, N Honke… - Journal of allergy and …, 2013 - Elsevier
BACKGROUND: Wiskott-Aldrich syndrome (WAS) is a rare X-linked primary
immunodeficiency caused by absence of Wiskott-Aldrich syndrome protein (WASP)
expression, resulting in defective function of many immune cell lineages and susceptibility to
severe bacterial, viral, and fungal infections. Despite a significant proportion of patients with
WAS having recurrent viral infections, surprisingly little is known about the effects of WASP
deficiency on antiviral immunity. OBJECTIVE: We sought to evaluate the antiviral immune …
immunodeficiency caused by absence of Wiskott-Aldrich syndrome protein (WASP)
expression, resulting in defective function of many immune cell lineages and susceptibility to
severe bacterial, viral, and fungal infections. Despite a significant proportion of patients with
WAS having recurrent viral infections, surprisingly little is known about the effects of WASP
deficiency on antiviral immunity. OBJECTIVE: We sought to evaluate the antiviral immune …