[HTML][HTML] Both WFIKKN1 and WFIKKN2 have high affinity for growth and differentiation factors 8 and 11
K Kondás, G Szláma, M Trexler, L Patthy - Journal of biological chemistry, 2008 - ASBMB
WFIKKN1 and WFIKKN2 are large extracellular multidomain proteins consisting of a WAP, a
follistatin, an immunoglobulin, two Kunitz-type protease inhibitor domains, and an NTR
domain. Recent experiments have shown that WFIKKN2 protein binds mature
GDF8/myostatin and myostatin propeptide and inhibits the biological activity of myostatin
(Hill, JJ, Qiu, Y., Hewick, RM, and Wolfman, NM (2003) Mol. Endocrinol. 17, 1144–1154).
Here we show that the paralogue of this protein, WFIKKN1, also binds to both myostatin and …
follistatin, an immunoglobulin, two Kunitz-type protease inhibitor domains, and an NTR
domain. Recent experiments have shown that WFIKKN2 protein binds mature
GDF8/myostatin and myostatin propeptide and inhibits the biological activity of myostatin
(Hill, JJ, Qiu, Y., Hewick, RM, and Wolfman, NM (2003) Mol. Endocrinol. 17, 1144–1154).
Here we show that the paralogue of this protein, WFIKKN1, also binds to both myostatin and …