Lipopolysaccharide induces sickness behaviour in rats by a vagal mediated mechanism.
RM Bluthé, V Walter, P Parnet, S Laye… - Comptes rendus de l' …, 1994 - europepmc.org
RM Bluthé, V Walter, P Parnet, S Laye, J Lestage, D Verrier, S Poole, BE Stenning…
Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie, 1994•europepmc.orgTo assess the possibility that lipopolysaccharide (LPS) induces sickness behaviour by
activating primary afferent nerves, the effects of LPS (1.25 mg kg-1, intraperitoneally) were
compared in vagotomized and sham-operated rats. Subdiaphragmatic vagotomy blocked
the LPS-induced depression of social investigation but had no effect on LPS-induced
increases in levels of IL-1 beta in plasma and peritoneal macrophages and on LPS-induced
changes in dehydrogenase activity of peritoneal macrophages.
activating primary afferent nerves, the effects of LPS (1.25 mg kg-1, intraperitoneally) were
compared in vagotomized and sham-operated rats. Subdiaphragmatic vagotomy blocked
the LPS-induced depression of social investigation but had no effect on LPS-induced
increases in levels of IL-1 beta in plasma and peritoneal macrophages and on LPS-induced
changes in dehydrogenase activity of peritoneal macrophages.
To assess the possibility that lipopolysaccharide (LPS) induces sickness behaviour by activating primary afferent nerves, the effects of LPS (1.25 mg kg-1, intraperitoneally) were compared in vagotomized and sham-operated rats. Subdiaphragmatic vagotomy blocked the LPS-induced depression of social investigation but had no effect on LPS-induced increases in levels of IL-1 beta in plasma and peritoneal macrophages and on LPS-induced changes in dehydrogenase activity of peritoneal macrophages.
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