Vagal afferent signaling of a gastric mucosal acid insult to medullary, pontine, thalamic, hypothalamic and limbic, but not cortical, nuclei of the rat brain
T Michl, M Jocič, A Heinemann, R Schuligoi, P Holzer - Pain, 2001 - Elsevier
Although gastric acid is a factor in upper abdominal pain, the signaling and processing of a
gastric mucosal acid insult within the brain are not known. This study examined which nuclei
in the rat brain respond to challenge of the gastric mucosa by a noxious concentration of
hydrochloric acid (HCl) and whether the central input is carried by vagal afferent neurons.
Activation of neurons in the brain was mapped by in situ hybridization autoradiography of
messenger ribonucleic acid (mRNA) for the immediate early gene c-fos 45 min after …
gastric mucosal acid insult within the brain are not known. This study examined which nuclei
in the rat brain respond to challenge of the gastric mucosa by a noxious concentration of
hydrochloric acid (HCl) and whether the central input is carried by vagal afferent neurons.
Activation of neurons in the brain was mapped by in situ hybridization autoradiography of
messenger ribonucleic acid (mRNA) for the immediate early gene c-fos 45 min after …