Pulmonary hypertension associated with long-term inhalation of “crank” methamphetamine
PH Schaiberger, TC Kennedy, FC Miller, J Gal, TL Petty - Chest, 1993 - Elsevier
We present the case of a 33-year-old white male truck driver with a ten-year history of 3.5-
g/wk “crank and “peanut butter methamphetamme inhalation (methamphetamine and
propylhexedrine, respectively). This patient developed marked pulmonary hypertension as a
probable consequence of abuse of these drugs. Proposed mechanisms of disease invoke
toxic endothelial injury, hypoxic insult, direct spasm, vasculitis, and dysregulation of
mediators of vascular tone. The possible role of genetics is discussed in reference to …
g/wk “crank and “peanut butter methamphetamme inhalation (methamphetamine and
propylhexedrine, respectively). This patient developed marked pulmonary hypertension as a
probable consequence of abuse of these drugs. Proposed mechanisms of disease invoke
toxic endothelial injury, hypoxic insult, direct spasm, vasculitis, and dysregulation of
mediators of vascular tone. The possible role of genetics is discussed in reference to …