Calorie restriction upregulated sirtuin 1 by attenuating its ubiquitin degradation in cancer cells
L Han, G Zhao, H Wang, T Tong… - Clinical and Experimental …, 2014 - Wiley Online Library
L Han, G Zhao, H Wang, T Tong, J Chen
Clinical and Experimental Pharmacology and Physiology, 2014•Wiley Online LibrarySirtuin (SIRT) 1 is a key protein in mediating the benefits of calorie restriction (CR) in
mammals. However, the molecular mechanisms underlying CR‐induced SIRT 1
upregulation in mammals remain unclear. Herein we show that the elevated SIRT 1 levels
are not due to increased SIRT1 mRNA expression. but rather to enhanced SIRT 1 protein
stability as a result of reduced ubiquitin‐proteasome degradation of SIRT 1 under limited
nutrient conditions. Our observations have important implications for improving healthy …
mammals. However, the molecular mechanisms underlying CR‐induced SIRT 1
upregulation in mammals remain unclear. Herein we show that the elevated SIRT 1 levels
are not due to increased SIRT1 mRNA expression. but rather to enhanced SIRT 1 protein
stability as a result of reduced ubiquitin‐proteasome degradation of SIRT 1 under limited
nutrient conditions. Our observations have important implications for improving healthy …
Summary
Sirtuin (SIRT) 1 is a key protein in mediating the benefits of calorie restriction (CR) in mammals. However, the molecular mechanisms underlying CR‐induced SIRT1 upregulation in mammals remain unclear. Herein we show that the elevated SIRT1 levels are not due to increased SIRT1 mRNA expression. but rather to enhanced SIRT1 protein stability as a result of reduced ubiquitin‐proteasome degradation of SIRT1 under limited nutrient conditions. Our observations have important implications for improving healthy aging in humans.
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