Prenatal 3, 4-methylenedioxymethamphetamine (ecstasy) alters exploratory behavior, reduces monoamine metabolism, and increases forebrain tyrosine hydroxylase …

JB Koprich, EY Chen, NM Kanaan… - Neurotoxicology and …, 2003 - Elsevier
3, 4-Methylenedioxymethamphetamine (MDMA; ecstasy) use has risen among women of
childbearing age. Consequently, there is a substantial risk for fetal exposure from women
who are, or become pregnant while abusing MDMA. However, attempts to demonstrate that
prenatal MDMA results in neurochemical alterations in rat models have failed. MDMA
administration to neonatal rats (third trimester equivalent) results in significant and persistent
neurochemical and behavioral alterations, yet human epidemiologic data suggest that the …