Association of α-, β-, and γ-synuclein with diffuse Lewy body disease
K Nishioka, C Wider, C Vilarino-Güell… - Archives of …, 2010 - jamanetwork.com
Objective To determine the association of the genes that encode α-, β-, and γ-synuclein
(SNCA, SNCB, andSNCG, respectively) with diffuse Lewy body disease (DLBD). Design
Case-control study. Subjects A total of 172 patients with DLBD consistent with a clinical
diagnosis of Parkinson disease dementia/dementia with Lewy bodies and 350 clinically and
97 pathologically normal controls. Interventions Sequencing ofSNCA, SNCB, andSNCGand
genotyping of single-nucleotide polymorphisms performed on an Applied Biosystems …
(SNCA, SNCB, andSNCG, respectively) with diffuse Lewy body disease (DLBD). Design
Case-control study. Subjects A total of 172 patients with DLBD consistent with a clinical
diagnosis of Parkinson disease dementia/dementia with Lewy bodies and 350 clinically and
97 pathologically normal controls. Interventions Sequencing ofSNCA, SNCB, andSNCGand
genotyping of single-nucleotide polymorphisms performed on an Applied Biosystems …