Background & Aims Mucosal-associated invariant T (MAIT) cells, the most abundant innate-
like T cells in the human liver, can be activated by cytokines during viral infection without
TCR stimulation. Here, we examined the mechanisms underlying TCR/MR1-independent
innate-like cytotoxicity of cytokine-activated liver MAIT cells. We also examined the
phenotype and function of MAIT cells from patients with acute viral hepatitis. Methods We
obtained liver sinusoidal mononuclear cells from donor liver perfusate during liver …