Synthesis and anti-inflammatory/antioxidant activities of some new ring substituted 3-phenyl-1-(1, 4-di-N-oxide quinoxalin-2-yl)-2-propen-1-one derivatives and of their …

A Burguete, E Pontiki, D Hadjipavlou-Litina… - Bioorganic & medicinal …, 2007 - Elsevier
A Burguete, E Pontiki, D Hadjipavlou-Litina, R Villar, E Vicente, B Solano, S Ancizu…
Bioorganic & medicinal chemistry letters, 2007Elsevier
We report the synthesis, anti-inflammatory and antioxidant activities of novel ring substituted
3-phenyl-1-(1, 4-di-N-oxide quinoxalin-2-yl)-2-propen-1-one derivatives and of their 4, 5-
dihydro-(1H)-pyrazole analogues. The tested compounds inhibit the carrageenin-induced
rat paw edema (4.5–56.1%) and present important scavenging activities. Compound 2a is
the most potent (56.1%) in the in vivo experiment and exhibits promising in vitro inhibition of
soybean lipoxygenase (IC50< 1μM).
We report the synthesis, anti-inflammatory and antioxidant activities of novel ring substituted 3-phenyl-1-(1,4-di-N-oxide quinoxalin-2-yl)-2-propen-1-one derivatives and of their 4,5-dihydro-(1H)-pyrazole analogues. The tested compounds inhibit the carrageenin-induced rat paw edema (4.5–56.1%) and present important scavenging activities. Compound 2a is the most potent (56.1%) in the in vivo experiment and exhibits promising in vitro inhibition of soybean lipoxygenase (IC50<1μM).
Elsevier