Paeoniflorin reduces neomycin-induced ototoxicity in hair cells by suppression of reactive oxygen species generation and extracellularly regulated kinase …
X Yu, Z Fan, Y Han, D Zhang, L Xu, M Wang, Q Yang… - Toxicology Letters, 2018 - Elsevier
The present study was designed to investigate the effect of paeoniflorin (PF) on neomycin-
induced ototoxicity in hair cells (HCs). Here, we took advantage of C57BL/6 mice and
cochlear explants culture to determine the role of PF in vivo and in vitro. We demonstrated
that neomycin exposure induced severe hearing loss and HC damage, which was mediated
by activated mitochondrial apoptosis pathway, promoted extracellular signal‐regulated
kinase (ERK) signaling as well as enhanced reactive oxygen species (ROS) generation in …
induced ototoxicity in hair cells (HCs). Here, we took advantage of C57BL/6 mice and
cochlear explants culture to determine the role of PF in vivo and in vitro. We demonstrated
that neomycin exposure induced severe hearing loss and HC damage, which was mediated
by activated mitochondrial apoptosis pathway, promoted extracellular signal‐regulated
kinase (ERK) signaling as well as enhanced reactive oxygen species (ROS) generation in …