The expression of oxidative stress response genes is modulated by a combination of resveratrol and N-acetylcysteine to ameliorate ototoxicity in the rat cochlea
F Garcia-Alcantara, S Murillo-Cuesta, S Pulido… - Hearing research, 2018 - Elsevier
Aminoglycoside antibiotics are used widely in medicine despite their ototoxic side-effects.
Oxidative stress and inflammation are key mechanisms determining the extent and severity
of the damage. Here we evaluate the protective effect of a treatment with resveratrol plus N-
acetylcysteine on the ototoxic actions of kanamycin and furosemide in the rat. Resveratrol
(10 mg/kg) and N-acetylcysteine (400 mg/kg) were administered together to Wistar rats on 5
consecutive days. The second day, a concentrated solution of kanamycin and furosemide …
Oxidative stress and inflammation are key mechanisms determining the extent and severity
of the damage. Here we evaluate the protective effect of a treatment with resveratrol plus N-
acetylcysteine on the ototoxic actions of kanamycin and furosemide in the rat. Resveratrol
(10 mg/kg) and N-acetylcysteine (400 mg/kg) were administered together to Wistar rats on 5
consecutive days. The second day, a concentrated solution of kanamycin and furosemide …