[HTML][HTML] Stabilization of basally translated NF-κB-inducing kinase (NIK) protein functions as a molecular switch of processing of NF-κB2 p100
G Qing, Z Qu, G Xiao - Journal of Biological Chemistry, 2005 - ASBMB
The non-canonical pathway based on processing of NF-κB2 precursor protein p100 to
generate p52 plays a critical role in controlling B cell function and lymphoid organogenesis.
Activation of this unique pathway by extracellular stimuli requires NF-κB-inducing kinase
(NIK) and de novo protein synthesis. However, how NIK is regulated is largely unknown.
Here, we systematically analyzed NIK expression at different levels in the presence or
absence of different NF-κB stimuli. We found that NIK mRNA is relatively abundant and …
generate p52 plays a critical role in controlling B cell function and lymphoid organogenesis.
Activation of this unique pathway by extracellular stimuli requires NF-κB-inducing kinase
(NIK) and de novo protein synthesis. However, how NIK is regulated is largely unknown.
Here, we systematically analyzed NIK expression at different levels in the presence or
absence of different NF-κB stimuli. We found that NIK mRNA is relatively abundant and …