[HTML][HTML] Oncovirus Kaposi sarcoma herpesvirus (KSHV) represses tumor suppressor PDLIM2 to persistently activate nuclear factor κB (NF-κB) and STAT3 transcription …
F Sun, Y Xiao, Z Qu - Journal of Biological Chemistry, 2015 - ASBMB
Kaposi sarcoma herpesvirus (KSHV) is the most common cause of malignancies among
AIDS patients. However, how KSHV induces tumorigenesis remains largely unknown. Here,
we demonstrate that one important mechanism underlying the tumorigenesis of KSHV is
through transcriptional repression of the tumor suppressor gene PDZ-LIM domain-
containing protein 2 (PDLIM2). PDLIM2 expression is repressed in KSHV-transformed
human umbilical vascular endothelial cells as well as in KSHV-associated cancer cell lines …
AIDS patients. However, how KSHV induces tumorigenesis remains largely unknown. Here,
we demonstrate that one important mechanism underlying the tumorigenesis of KSHV is
through transcriptional repression of the tumor suppressor gene PDZ-LIM domain-
containing protein 2 (PDLIM2). PDLIM2 expression is repressed in KSHV-transformed
human umbilical vascular endothelial cells as well as in KSHV-associated cancer cell lines …