CD226hiCD8+ T Cells Are a Prerequisite for Anti-TIGIT Immunotherapy

H Jin, M Ko, D Choi, JH Kim, D Lee, SH Kang… - Cancer immunology …, 2020 - AACR
H Jin, M Ko, D Choi, JH Kim, D Lee, SH Kang, I Kim, HJ Lee, EK Choi, K Kim, C Yoo, Y Park
Cancer immunology research, 2020AACR
Clinical trials are evaluating the efficacy of anti-TIGIT for use as single-agent therapy or in
combination with programmed death 1 (PD-1)/programmed death-ligand 1 blockade. How
and whether a TIGIT blockade will synergize with immunotherapies is not clear. Here, we
show that CD226loCD8+ T cells accumulate at the tumor site and have an exhausted
phenotype with impaired functionality. In contrast, CD226hiCD8+ tumor-infiltrating T cells
possess greater self-renewal capacity and responsiveness. Anti-TIGIT treatment selectively …
Abstract
Clinical trials are evaluating the efficacy of anti-TIGIT for use as single-agent therapy or in combination with programmed death 1 (PD-1)/programmed death-ligand 1 blockade. How and whether a TIGIT blockade will synergize with immunotherapies is not clear. Here, we show that CD226loCD8+ T cells accumulate at the tumor site and have an exhausted phenotype with impaired functionality. In contrast, CD226hiCD8+ tumor-infiltrating T cells possess greater self-renewal capacity and responsiveness. Anti-TIGIT treatment selectively affects CD226hiCD8+ T cells by promoting CD226 phosphorylation at tyrosine 322. CD226 agonist antibody-mediated activation of CD226 augments the effect of TIGIT blockade on CD8+ T-cell responses. Finally, mFOLFIRINOX treatment, which increases CD226hiCD8+ T cells in patients with pancreatic ductal adenocarcinoma, potentiates the effects of TIGIT or PD-1 blockade. Our results implicate CD226 as a predictive biomarker for cancer immunotherapy and suggest that increasing numbers of CD226hiCD8+ T cells may improve responses to anti-TIGIT therapy.
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