[HTML][HTML] Is PML a tumor suppressor?

M Mazza, PG Pelicci - Frontiers in oncology, 2013 - frontiersin.org
M Mazza, PG Pelicci
Frontiers in oncology, 2013frontiersin.org
The role of the promyelocytic leukemia (PML) protein has been widely tested in many
different contexts, as attested by the hundreds of papers present in the literature. In most of
these studies, PML is regarded as a tumor suppressor, a notion on the whole accepted by
the scientific community. In this review, we examine how the concept of tumor-suppressor
gene has evolved until now and then systematically assess whether this assumption for PML
is supported by unambiguous experimental evidence.
The role of the promyelocytic leukemia (PML) protein has been widely tested in many different contexts, as attested by the hundreds of papers present in the literature. In most of these studies, PML is regarded as a tumor suppressor, a notion on the whole accepted by the scientific community. In this review, we examine how the concept of tumor-suppressor gene has evolved until now and then systematically assess whether this assumption for PML is supported by unambiguous experimental evidence.
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