Treatment of severe colchicine overdose with colchicine-specific Fab fragments
FJ Baud, A Sabouraud, E Vicaut… - … England Journal of …, 1995 - Mass Medical Soc
New England Journal of Medicine, 1995•Mass Medical Soc
The use of colchicine is limited by its toxicity, 1 and colchicine overdose is associated with a
high mortality rate. Patients with early hemodynamic collapse due to colchicine overdose
have particularly poor prognoses, 2, 3 and there has been no effective treatment for this
complication of severe colchicine intoxication. 4 Colchicine binds reversibly to tubulin, 5 and
colchicine-specific antibodies have been shown to restore the activity of tubulin in vitro. 6, 7
Colchicine-specific active immunization in rabbits and passive immunization in mice with …
high mortality rate. Patients with early hemodynamic collapse due to colchicine overdose
have particularly poor prognoses, 2, 3 and there has been no effective treatment for this
complication of severe colchicine intoxication. 4 Colchicine binds reversibly to tubulin, 5 and
colchicine-specific antibodies have been shown to restore the activity of tubulin in vitro. 6, 7
Colchicine-specific active immunization in rabbits and passive immunization in mice with …
The use of colchicine is limited by its toxicity,1 and colchicine overdose is associated with a high mortality rate. Patients with early hemodynamic collapse due to colchicine overdose have particularly poor prognoses,2,3 and there has been no effective treatment for this complication of severe colchicine intoxication.4
Colchicine binds reversibly to tubulin,5 and colchicine-specific antibodies have been shown to restore the activity of tubulin in vitro.6,7 Colchicine-specific active immunization in rabbits and passive immunization in mice with substoichiometric doses of goat colchicine-specific antibodies and their Fab fragments have been shown to prevent or reverse acute colchicine poisoning.8–11 These . . .
The New England Journal Of Medicine