Cellular senescence is a mechanism by which cells permanently withdraw from the cell
cycle in response to stresses including telomere shortening, DNA damage, or oncogenic
signaling. Senescent cells contribute to both age-related degeneration and hyperplastic
pathologies, including cancer. In culture, normal human epithelial cells enter senescence
after a limited number of cell divisions, known as replicative senescence. Here, to
investigate how metabolic pathways regulate replicative senescence, we used LC-MS …