[HTML][HTML] Extracellular ATP-mediated signaling for survival in hyperoxia-induced oxidative stress

S Ahmad, A Ahmad, M Ghosh, CC Leslie… - Journal of Biological …, 2004 - ASBMB
Respiratory failure is a serious consequence of lung cell injury caused by treatment with
high inhaled oxygen concentrations. Human lung microvascular endothelial cells (HLMVEC)
are a principal target of hyperoxic injury (hyperoxia). Cell stress can cause release of ATP,
and this extracellular nucleotide can activate purinoreceptors and mediate responses
essential for survival. In this investigation, exposure of endothelial cells to an oxidative
stress, hyperoxia, caused rapid but transient ATP release (20.03±2.00 nm/10 6 cells in 95 …