[HTML][HTML] Glucose-6-phosphate dehydrogenase modulates vascular endothelial growth factor-mediated angiogenesis
JA Leopold, J Walker, AW Scribner, B Voetsch… - Journal of Biological …, 2003 - ASBMB
Glucose-6-phosphate dehydrogenase (G6PD), the first enzyme of the pentose phosphate
pathway, is the principal intracellular source of NADPH. NADPH is utilized as a cofactor by
vascular endothelial cell nitric-oxide synthase (eNOS) to generate nitric oxide (NO•). To
determine whether G6PD modulates NO•-mediated angiogenesis, we decreased G6PD
expression in bovine aortic endothelial cells using an antisense oligodeoxynucleotide to
G6PD or increased G6PD expression by adenoviral gene transfer, and we examined …
pathway, is the principal intracellular source of NADPH. NADPH is utilized as a cofactor by
vascular endothelial cell nitric-oxide synthase (eNOS) to generate nitric oxide (NO•). To
determine whether G6PD modulates NO•-mediated angiogenesis, we decreased G6PD
expression in bovine aortic endothelial cells using an antisense oligodeoxynucleotide to
G6PD or increased G6PD expression by adenoviral gene transfer, and we examined …
