[HTML][HTML] Transforming growth factor β2 (TGFβ2) signaling plays a key role in glucocorticoid-induced ocular hypertension
Elevation of intraocular pressure (IOP) is a serious adverse effect of glucocorticoid (GC)
therapy. Increased extracellular matrix (ECM) accumulation and endoplasmic reticulum (ER)
stress in the trabecular meshwork (TM) is associated with GC-induced IOP elevation.
However, the molecular mechanisms by which GCs induce ECM accumulation and ER
stress in the TM have not been determined. Here, we show that a potent GC,
dexamethasone (Dex), activates transforming growth factor β (TGFβ) signaling, leading to …
therapy. Increased extracellular matrix (ECM) accumulation and endoplasmic reticulum (ER)
stress in the trabecular meshwork (TM) is associated with GC-induced IOP elevation.
However, the molecular mechanisms by which GCs induce ECM accumulation and ER
stress in the TM have not been determined. Here, we show that a potent GC,
dexamethasone (Dex), activates transforming growth factor β (TGFβ) signaling, leading to …