The Asian atopic dermatitis phenotype combines features of atopic dermatitis and psoriasis with increased TH17 polarization
Background Atopic dermatitis (AD) shows very high prevalence in Asia, with a large unmet
need for effective therapeutics. Direct comparisons between European American (EA) and
Asian patients with AD are unavailable, but earlier blood studies detected increased IL-17+–
producing cell counts in Asian patients with AD. Objective We sought to characterize the
Asian AD skin phenotype and compare it with the EA AD skin phenotype. Methods We
performed genomic profiling (real-time PCR) and immunohistochemistry on lesional and …
need for effective therapeutics. Direct comparisons between European American (EA) and
Asian patients with AD are unavailable, but earlier blood studies detected increased IL-17+–
producing cell counts in Asian patients with AD. Objective We sought to characterize the
Asian AD skin phenotype and compare it with the EA AD skin phenotype. Methods We
performed genomic profiling (real-time PCR) and immunohistochemistry on lesional and …