Thymic stromal lymphopoietin downregulates filaggrin expression by signal transducer and activator of transcription 3 (STAT3) and extracellular signal-regulated …
JH Kim, HC Bae, NY Ko, SH Lee, SH Jeong… - Journal of Allergy and …, 2015 - jacionline.org
The present study shows that human keratinocytes and skin express the receptor for TSLP.
We investigated whether TSLP is involved in filaggrin expression in primary human
keratinocytes. Furthermore, we identified the signaling molecules that conduct the inhibitory
action of TSLP on filaggrin synthesis in keratinocytes. The TSLP receptor complex consists
of the IL-7 receptor (IL-7R) a chain and a TSLP-binding chain (also known as the type I
cytokine receptor subunit cytokine receptor-like factor 2 [CRLF2]). 5 To define the presence …
We investigated whether TSLP is involved in filaggrin expression in primary human
keratinocytes. Furthermore, we identified the signaling molecules that conduct the inhibitory
action of TSLP on filaggrin synthesis in keratinocytes. The TSLP receptor complex consists
of the IL-7 receptor (IL-7R) a chain and a TSLP-binding chain (also known as the type I
cytokine receptor subunit cytokine receptor-like factor 2 [CRLF2]). 5 To define the presence …
