[HTML][HTML] Serum amyloid A inhibits dendritic cell differentiation by suppressing GM-CSF receptor expression and signaling
JC Kim, YS Jung, HY Lee, JS Park… - Experimental & molecular …, 2017 - nature.com
JC Kim, YS Jung, HY Lee, JS Park, YS Bae
Experimental & molecular medicine, 2017•nature.comIn this study, we report that an acute phase reactant, serum amyloid A (SAA), strongly
inhibits dendritic cell differentiation induced by GM-CSF plus IL-4. SAA markedly decreased
the expression of MHCII and CD11c. Moreover, SAA decreased cell surface GM-CSF
receptor expression. SAA also decreased the expression of PU. 1 and C/EBPα, which play
roles in the expression of GM-CSF receptor. This inhibitory response by SAA is partly
mediated by the well-known SAA receptors, Toll-like receptor 2 and formyl peptide receptor …
inhibits dendritic cell differentiation induced by GM-CSF plus IL-4. SAA markedly decreased
the expression of MHCII and CD11c. Moreover, SAA decreased cell surface GM-CSF
receptor expression. SAA also decreased the expression of PU. 1 and C/EBPα, which play
roles in the expression of GM-CSF receptor. This inhibitory response by SAA is partly
mediated by the well-known SAA receptors, Toll-like receptor 2 and formyl peptide receptor …
Abstract
In this study, we report that an acute phase reactant, serum amyloid A (SAA), strongly inhibits dendritic cell differentiation induced by GM-CSF plus IL-4. SAA markedly decreased the expression of MHCII and CD11c. Moreover, SAA decreased cell surface GM-CSF receptor expression. SAA also decreased the expression of PU. 1 and C/EBPα, which play roles in the expression of GM-CSF receptor. This inhibitory response by SAA is partly mediated by the well-known SAA receptors, Toll-like receptor 2 and formyl peptide receptor 2. Taken together, we suggest a novel insight into the inhibitory role of SAA in dendritic cell differentiation.
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