Itolizumab, a novel anti-CD6 monoclonal antibody: a safe and efficacious biologic agent for management of psoriasis
S Dogra, S Uprety, SH Suresh - Expert opinion on biological …, 2017 - Taylor & Francis
S Dogra, S Uprety, SH Suresh
Expert opinion on biological therapy, 2017•Taylor & FrancisIntroduction: Psoriasis, a chronic immune-mediated skin disorder is associated with
significant physical, psychological, and quality of life impairments. Along with well-
documented genetic and environmental factors, immunological factors also contribute to the
pathogenesis of psoriasis. Among the immunological factors, CD6–dependent T-cell
proliferation to form Th1 and Th17 cells play a major role in the pathogenesis of psoriasis.
Itolizumab is the first humanized IgG1 monoclonal antibody, which selectively targets CD6 …
significant physical, psychological, and quality of life impairments. Along with well-
documented genetic and environmental factors, immunological factors also contribute to the
pathogenesis of psoriasis. Among the immunological factors, CD6–dependent T-cell
proliferation to form Th1 and Th17 cells play a major role in the pathogenesis of psoriasis.
Itolizumab is the first humanized IgG1 monoclonal antibody, which selectively targets CD6 …
Abstract
Introduction: Psoriasis, a chronic immune-mediated skin disorder is associated with significant physical, psychological, and quality of life impairments. Along with well-documented genetic and environmental factors, immunological factors also contribute to the pathogenesis of psoriasis. Among the immunological factors, CD6 – dependent T-cell proliferation to form Th1 and Th17 cells play a major role in the pathogenesis of psoriasis. Itolizumab is the first humanized IgG1 monoclonal antibody, which selectively targets CD6.
Areas covered: The current article presents the pharmacology of itolizumab and provides a review of the currently available data on the efficacy and safety of itolizumab for management of moderate to severe plaque psoriasis.
Expert opinion: The use of biologics to attenuate the immune-mediated pathological events in psoriasis is a relatively well-established clinical practice. However, the safety and efficacy of biologics continues to be an unsettled topic of ongoing research. While available data seems to suggest that itolizumab may be a safer option, additional studies with higher sample sizes and active comparators are needed before definitive conclusions can be drawn on the place of itolizumab in the management of psoriasis.
Taylor & Francis Online