Krüppel-like factor 14, a coronary artery disease associated transcription factor, inhibits endothelial inflammation via NF-κB signaling pathway

W Hu, H Lu, J Zhang, Y Fan, Z Chang, W Liang… - Atherosclerosis, 2018 - Elsevier
Background and aims Human genetic studies indicated that variations near the transcription
factor Krüppel-like factor 14 (KLF14) gene locus are highly associated with coronary artery
disease. Activation of endothelial cells (ECs) by pro-inflammatory molecules and pathways
is a primary step in atherosclerosis development. We aimed to investigate the effects and
mechanism of KLF14 on inflammatory responses in ECs. Methods Adenovirus-mediated
overexpression of human KLF14 and EC specific Klf14 knockout mice were applied to study …