The role matrix metalloproteinases in the production of aortic aneurysm
SW Rabkin - Progress in molecular biology and translational …, 2017 - Elsevier
Matrix metalloproteinases (MMPs) have been implicated in the pathogenesis of aortic
aneurysm because the histology of thoracic aortic aneurysm (TAA) and abdominal aortic
aneurysm (AAA) is characterized by the loss of smooth muscle cells in the aortic media and
the destruction of extracellular matrix (ECM). Furthermore, AAA have evidence of
inflammation and the cellular elements involved in inflammation such as macrophages can
produce and/or activate MMPs This chapter focuses on human aortic aneurysm that are not …
aneurysm because the histology of thoracic aortic aneurysm (TAA) and abdominal aortic
aneurysm (AAA) is characterized by the loss of smooth muscle cells in the aortic media and
the destruction of extracellular matrix (ECM). Furthermore, AAA have evidence of
inflammation and the cellular elements involved in inflammation such as macrophages can
produce and/or activate MMPs This chapter focuses on human aortic aneurysm that are not …