Rhinovirus infection induces expression of type 2 nitric oxide synthase in human respiratory epithelial cells in vitro and in vivo
SP Sanders, ES Siekierski, SM Richards… - Journal of allergy and …, 2001 - Elsevier
Background: Human rhinovirus (HRV) infections are the predominant cause of the common
cold and are associated with exacerbations of asthma. Nitric oxide (NO) may play an
important role in host defense by means of its potent antiviral properties. Objective: We
sought to determine whether epithelial expression of type 2 nitric oxide synthase (NOS 2),
which produces NO, is induced on rhinovirus infection in vitro and in vivo. Methods: Primary
cultures of human airway epithelial cells were infected with HRV-16, and NOS 2 mRNA …
cold and are associated with exacerbations of asthma. Nitric oxide (NO) may play an
important role in host defense by means of its potent antiviral properties. Objective: We
sought to determine whether epithelial expression of type 2 nitric oxide synthase (NOS 2),
which produces NO, is induced on rhinovirus infection in vitro and in vivo. Methods: Primary
cultures of human airway epithelial cells were infected with HRV-16, and NOS 2 mRNA …