Hepatocyte-derived macrophage migration inhibitory factor mediates alcohol-induced liver injury in mice and patients
Background & Aims Macrophage migration inhibitory factor (MIF) is a multi-potent cytokine
that contributes to the inflammatory response to injury. MIF is expressed by multiple cell
types; however, the cellular source and actions of MIF in alcoholic liver disease (ALD) are
not well known. Here we tested the hypothesis that non-myeloid cells, specifically
hepatocytes, are an important cellular source of MIF in ALD. Methods MIF expression was
measured in HuH7 and differentiated THP-1 cells in response to ethanol. Ethanol-induced …
that contributes to the inflammatory response to injury. MIF is expressed by multiple cell
types; however, the cellular source and actions of MIF in alcoholic liver disease (ALD) are
not well known. Here we tested the hypothesis that non-myeloid cells, specifically
hepatocytes, are an important cellular source of MIF in ALD. Methods MIF expression was
measured in HuH7 and differentiated THP-1 cells in response to ethanol. Ethanol-induced …
