[PDF][PDF] Novel splice variants of IL-33: differential expression in normal and transformed cells

H Tsuda, M Komine, M Karakawa, T Etoh… - The Journal of …, 2012 - core.ac.uk
H Tsuda, M Komine, M Karakawa, T Etoh, S Tominaga, M Ohtsuki
The Journal of Investigative Dermatology, 2012core.ac.uk
IL-33 is a newly discovered member of the IL-1 family and is constitutively expressed in the
epithelial and endothelial cells of various organs (Moussion et al., 2008). IL-33 is important
to the T helper 2 (Th2) immune reaction because its receptor, ST2L, is expressed on Th2
lymphocytes, basophils, eosinophils, and mast cells (Schmitz et al., 2005). It may also
function independently of the immune reaction (Sanada et al., 2007). IL-33 is usually found
in the nucleus, produced as pro-form IL-33 (pro-IL-33), and is digested into a mature form …
IL-33 is a newly discovered member of the IL-1 family and is constitutively expressed in the epithelial and endothelial cells of various organs (Moussion et al., 2008). IL-33 is important to the T helper 2 (Th2) immune reaction because its receptor, ST2L, is expressed on Th2 lymphocytes, basophils, eosinophils, and mast cells (Schmitz et al., 2005). It may also function independently of the immune reaction (Sanada et al., 2007). IL-33 is usually found in the nucleus, produced as pro-form IL-33 (pro-IL-33), and is digested into a mature form with a lower molecular weight when it is secreted from the cells. Mature IL-33 was first thought to be the active form (Schmitz et al., 2005). However, recent reports have shown that the active pro-form of IL-33 is digested into an inactive mature form (Cayrol and Girard, 2009).
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