[HTML][HTML] Dissociation of inositol-requiring enzyme (IRE1α)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding …
Hepatic insulin resistance has been attributed to both increased endoplasmic reticulum (ER)
stress and accumulation of intracellular lipids, specifically diacylglycerol (DAG). The ER
stress response protein, X-box-binding protein-1 (XBP1), was recently shown to regulate
hepatic lipogenesis, suggesting that hepatic insulin resistance in models of ER stress may
result from defective lipid storage, as opposed to ER-specific stress signals. Studies were
designed to dissociate liver lipid accumulation and activation of ER stress signaling …
stress and accumulation of intracellular lipids, specifically diacylglycerol (DAG). The ER
stress response protein, X-box-binding protein-1 (XBP1), was recently shown to regulate
hepatic lipogenesis, suggesting that hepatic insulin resistance in models of ER stress may
result from defective lipid storage, as opposed to ER-specific stress signals. Studies were
designed to dissociate liver lipid accumulation and activation of ER stress signaling …