CD45RA depletion in HLA-mismatched allogeneic hematopoietic stem cell transplantation for primary combined immunodeficiency: A preliminary study
F Touzot, B Neven, L Dal-Cortivo, A Gabrion… - Journal of Allergy and …, 2015 - Elsevier
Background Combined immunodeficiencies (CIDs) form a heterogeneous group of inherited
conditions that affect the development, function, or both of T cells. The treatment of CIDs with
allogeneic hematopoietic stem cell transplantation (HSCT) is complicated by a high
incidence of life-threatening infections and an increased risk of graft-versus-host disease
(GVHD). Objective In view of the growing evidence that alloreactivity is mainly derived from
human naive T cells, the selective depletion of naive T cells from allografts might constitute a …
conditions that affect the development, function, or both of T cells. The treatment of CIDs with
allogeneic hematopoietic stem cell transplantation (HSCT) is complicated by a high
incidence of life-threatening infections and an increased risk of graft-versus-host disease
(GVHD). Objective In view of the growing evidence that alloreactivity is mainly derived from
human naive T cells, the selective depletion of naive T cells from allografts might constitute a …