[HTML][HTML] Anti-CD45RB monoclonal antibody prolongs renal allograft survival in cynomolgus monkeys
Previously, an anti-CD45RB monoclonal antibody (mAb) has been shown to induce murine
allograft tolerance. The present study was performed to assess the ability of an anti-human
CD45RB mAb to prevent rejection in a monkey MHC-mismatched kidney transplant model.
The recipients were allocated into the following treatment groups:(1) isotype control IgG;(2)
mouse anti-human CD45RB IgG1 (6G3);(3) human-mouse chimeric anti-CD45RB-IgG1
(C6G3-IgG1);(4) human-mouse chimeric anti-CD45RB-IgG2 (C6G3-IgG2);(5) tacrolimus at a …
allograft tolerance. The present study was performed to assess the ability of an anti-human
CD45RB mAb to prevent rejection in a monkey MHC-mismatched kidney transplant model.
The recipients were allocated into the following treatment groups:(1) isotype control IgG;(2)
mouse anti-human CD45RB IgG1 (6G3);(3) human-mouse chimeric anti-CD45RB-IgG1
(C6G3-IgG1);(4) human-mouse chimeric anti-CD45RB-IgG2 (C6G3-IgG2);(5) tacrolimus at a …
