[HTML][HTML] Prolongation of allograft survival by administration of anti-CD45RB monoclonal antibody is due to alteration of CD45RBhi: CD45RBlo T-cell proportions
PPW Luke, JP Deng, D Lian, PJ O'Connell… - American journal of …, 2006 - Elsevier
CD45RB monoclonal antibody (mAb) therapy is capable of prolonging allograft survival. We
have previously shown that CD45RB mAb enriches the CD45RB lo T-cell population in vitro
and in vivo by preferentially depleting CD45RB hi T cells. The present study assessed the
importance of CD45RB hi T-cell depletion in murine cardiac allograft survival by infusion of
naive CD45RB T-cell subsets. Here we show that naturally occurring CD45RB lo CD4+ T
cells express regulatory transcription factor Foxp3 and have regulatory function, whereas …
have previously shown that CD45RB mAb enriches the CD45RB lo T-cell population in vitro
and in vivo by preferentially depleting CD45RB hi T cells. The present study assessed the
importance of CD45RB hi T-cell depletion in murine cardiac allograft survival by infusion of
naive CD45RB T-cell subsets. Here we show that naturally occurring CD45RB lo CD4+ T
cells express regulatory transcription factor Foxp3 and have regulatory function, whereas …