In vivo viability of postmitotic Purkinje neurons requires pRb family member function
RM Feddersen, HB Clark, WS Yunis, HT Orr - Molecular and Cellular …, 1995 - Elsevier
The product of the retinoblastoma susceptibility gene, pRb, is known to be an important
regulator of cell division. Disrupted central nervous system development in RB null mice
suggests a critical function for pRb in the proliferative arrest and initiation of terminal
differentiation of certain neurons. Previously, we have shown that SV40 T-ag expression
targeted to Purkinje neurons in transgenic mice causes cell-specific death. Here we
describe that T-ag expression induces DNA synthesis and results in DNA fragmentation in …
regulator of cell division. Disrupted central nervous system development in RB null mice
suggests a critical function for pRb in the proliferative arrest and initiation of terminal
differentiation of certain neurons. Previously, we have shown that SV40 T-ag expression
targeted to Purkinje neurons in transgenic mice causes cell-specific death. Here we
describe that T-ag expression induces DNA synthesis and results in DNA fragmentation in …