Crosstalk between stem cell and cell cycle machineries
Highlights•The pluripotent state has a unique cell cycle relative to somatic cells.•Extensive
reciprocal crosstalk exists to maintain both pluripotency and a rapid cell cycle.•Unique cell
cycle maintains pluripotency by inhibiting differentiation.•iPS cell reprogramming re-
establishes the unique cell cycle of ES cells.Pluripotent stem cells, defined by an unlimited
self-renewal capacity and an undifferentiated state, are best typified by embryonic stem
cells. These cells have a unique cell cycle compared to somatic cells as defined by a rapid …
reciprocal crosstalk exists to maintain both pluripotency and a rapid cell cycle.•Unique cell
cycle maintains pluripotency by inhibiting differentiation.•iPS cell reprogramming re-
establishes the unique cell cycle of ES cells.Pluripotent stem cells, defined by an unlimited
self-renewal capacity and an undifferentiated state, are best typified by embryonic stem
cells. These cells have a unique cell cycle compared to somatic cells as defined by a rapid …
Highlights
- The pluripotent state has a unique cell cycle relative to somatic cells.
- Extensive reciprocal crosstalk exists to maintain both pluripotency and a rapid cell cycle.
- Unique cell cycle maintains pluripotency by inhibiting differentiation.
- iPS cell reprogramming re-establishes the unique cell cycle of ES cells.
Pluripotent stem cells, defined by an unlimited self-renewal capacity and an undifferentiated state, are best typified by embryonic stem cells. These cells have a unique cell cycle compared to somatic cells as defined by a rapid progression through the cell cycle and a minimal time spent in G1. Recent reports indicate that pluripotency and cell cycle regulation are mechanistically linked. In this review, we discuss the reciprocal co-regulation of these processes, how this co-regulation may prevent differentiation, and how cellular reprogramming can re-establish the unique cell cycle regulation in induced pluripotent stem cells.
Elsevier
