▪ Abstract Axon growth inhibitors associated with myelin and the glial scar contribute to the
failure of axon regeneration in the injured adult mammalian central nervous system (CNS). A
number of these inhibitors, their receptors, and signaling pathways have been identified.
These inhibitors can now be neutralized by a variety of approaches that point to the
possibility of developing new therapeutic strategies to stimulate regeneration after spinal
cord injury.