Perinatal encephalopathy remains a major cause of disability, such as cerebral palsy.
Therapeutic hypothermia is now well established to partially reduce risk of disability in late
preterm/term infants. However, new and complementary therapeutic targets are needed to
further improve outcomes. There is increasing evidence that glia play a key role in neural
damage after hypoxia-ischemia and infection/inflammation. In this review, we discuss the
role of astrocytic gap junction (connexin) hemichannels in the spread of neural injury after …