[HTML][HTML] Adaptation of connexin 43-hemichannel prostaglandin release to mechanical loading
AJ Siller-Jackson, S Burra, S Gu, X Xia… - Journal of Biological …, 2008 - ASBMB
Bone tissues respond to mechanical loading/unloading regimens to accommodate (re)
modeling requirements; however, the underlying molecular mechanism responsible for
these responses is largely unknown. Previously, we reported that connexin (Cx) 43
hemichannels in mechanosensing osteocytes mediate the release of prostaglandin, PGE 2,
a crucial factor for bone formation in response to anabolic loading. We show here that the
opening of hemichannels and release of PGE 2 by shear stress were significantly inhibited …
modeling requirements; however, the underlying molecular mechanism responsible for
these responses is largely unknown. Previously, we reported that connexin (Cx) 43
hemichannels in mechanosensing osteocytes mediate the release of prostaglandin, PGE 2,
a crucial factor for bone formation in response to anabolic loading. We show here that the
opening of hemichannels and release of PGE 2 by shear stress were significantly inhibited …