Blocking connexin43 expression reduces inflammation and improves functional recovery after spinal cord injury
M Cronin, PN Anderson, JE Cook, CR Green… - Molecular and Cellular …, 2008 - Elsevier
After traumatic CNS injury, a cascade of secondary events expands the initial lesion. The
gap-junction protein connexin43 (Cx43), which is transiently up-regulated, has been
implicated in the spread of 'bystander'damage. We have used an antisense
oligodeoxynucleotide (asODN) to suppress Cx43 up-regulation in two rat models of spinal
cord injury. Within 24 h of compression injury, rats treated with Cx43-asODN scored higher
than sense-ODN and vehicle-treated controls on behavioural tests of locomotion. Their …
gap-junction protein connexin43 (Cx43), which is transiently up-regulated, has been
implicated in the spread of 'bystander'damage. We have used an antisense
oligodeoxynucleotide (asODN) to suppress Cx43 up-regulation in two rat models of spinal
cord injury. Within 24 h of compression injury, rats treated with Cx43-asODN scored higher
than sense-ODN and vehicle-treated controls on behavioural tests of locomotion. Their …